Does downsizing take a toll on retained staff? An analysis of increased working hours during recessions using Japanese micro data

Using official household micro data from the Labour Force Survey, this paper examines the increase in the working hours of regular male employees in Japan under recession from the late 1990s to the early 2000s. The most important findings of this paper are that working hours tended to be longer among male regular employees of firms in which (1) there was major employment adjustment, (2) substantial increase in proportion of non-regular workers, and (3) wide variance in regular wages. The results suggest that the existence of a large amount of fixed duties that are necessary to maintain internal organization and transition from the traditional employment system are the main factors that explain the increase in the working hours during the recession in Japan.

Long-Term Effects of a Recession at Labor Market Entry in Japan and the United States

This paper examines effects of entering the labor market during a recession on subsequent earnings and employment for Japanese and American men, using comparable household labor force surveys. Previous analyses focus on search theoretic and implicit-contract arguments, which have their strongest effects on more educated workers. The authors argue that, in a country like Japan which has a dual labor market, there is an additional mechanism that affects mainly less educated workers. Namely, these workers are more likely to be trapped in the secondary sector if they graduate during a recession. We find a persistent, strong negative effect on earnings for less educated Japanese men, in contrast to no long-term effect for less educated American men; also, a substantial part of the effect for less educated Japanese men is attributed to the decreased probability of regular employment. The effect for the more educated group is more or less similar in both countries

Clonal hematopoiesis in adult pure red cell aplasia

Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse were associated with death. PRCA may represent the prodrome to MDS. Thus, clonal hematopoiesis may be responsible for treatment failure. We investigated gene mutations in myeloid neoplasm-associated genes in acquired PRCA. We identified 21 mutations affecting amino acid sequences in 11 of the 38 adult PRCA patients (28.9%) using stringent filtering of the error-prone sequences and SNPs. Four PRCA patients showed 7 driver mutations in TET2, DNMT3A and KDM6A, and 2 PRCA patients carried multiple mutations in TET2. Five PRCA patients had mutations with high VAFs exceeding 0.3. These results suggest that clonal hematopoiesis by stem/progenitor cells might be related to the pathophysiology of chronic PRCA in certain adult patients

エダラボン ノ ラット セキズイ ソンショウ ニ オケル シンケイ ホゴ オヨビ カイフク ソクシン サヨウ

京都大学0048新制・課程博士博士(医学)甲第11399号医博第2822号新制||医||887(附属図書館)23042UT51-2005-M985京都大学大学院医学研究科外科系専攻(主査)教授 鈴木 茂彦, 教授 淀井 淳司, 教授 井出 千束学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDA